⚠️ FOR RESEARCH PURPOSES ONLY — All compounds and data are for in vitro laboratory research and educational reference only. Not for human or animal use. Not evaluated by the FDA.
Research Library 28 Compounds

Research Peptide Blog Database

Peer-reviewed studies, clinical data, mechanism breakdowns, and molecular specifications — all in one place.

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Research Library Neuropeptide

KISS1 Neuropeptide · HPG Axis Regulator

Kisspeptin

HPG axis regulator. For in vitro research use only.

FormulaC63H83N15O13
Mol. Weight1302.46 g/mol
CAS374683-17-7
SequenceTyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2 (Kp-10)
PubMed Indexed Research Use Only

Published Scientific Research

Peer-reviewed studies investigating Kisspeptin sourced from PubMed-indexed journals for educational reference only.

Literature Review PubMed

The Role of Kisspeptin in the Control of the Hypothalamic-Pituitary-Gonadal Axis and Reproduction.

Frontiers in endocrinology 2022
Xie Q, Kang Y, Zhang C et al.

The discovery of kisspeptin as a critical central regulatory factor of GnRH release has given people a novel understanding of the neuroendocrine regulation in human reproduction. Kisspeptin activates the signaling pathway by binding to its...

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Research Article PubMed

Normal Puberty.

Endocrinology and metabolism clinics of North America 2024
Bangalore Krishna K, Witchel SF et al.

Puberty is characterized by gonadarche and adrenarche. Gonadarche represents the reactivation of the hypothalamic-pituitary-gonadal axis with increased gonadotropin-releasing hormone, luteinizing hormone, and follicle-stimulating hormone secretion following the quiescence during childhood. Pubarche is the development of...

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Mechanism Study PubMed

Pubertal development and regulation.

The lancet. Diabetes & endocrinology 2016
Abreu AP, Kaiser UB et al.

Puberty marks the end of childhood and is a period when individuals undergo physiological and psychological changes to achieve sexual maturation and fertility. The hypothalamic-pituitary-gonadal axis controls puberty and reproduction and is tightly regulated by...

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Literature Review PubMed

Hypothalamo-Pituitary axis and puberty.

Molecular and cellular endocrinology 2021
Spaziani M, Tarantino C, Tahani N et al.

Puberty is a complex process that culminates in the acquisition of psychophysical maturity and reproductive capacity. This elaborate and fascinating process marks the end of childhood. Behind it lies a complex, genetically mediated neuroendocrine mechanism...

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Literature Review PubMed

The hypothalamus-pituitary-gonad axis: Tales of mice and men.

Metabolism: clinical and experimental 2018
Kaprara A, Huhtaniemi IT et al.

Reproduction is controlled by the hypothalamic-pituitary-gonadal (HPG) axis. Gonadotropin-releasing hormone (GnRH) neurons play a central role in this axis through production of GnRH, which binds to a membrane receptor on pituitary gonadotrophs and stimulates the...

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Literature Review PubMed

Sex differences in circadian timing systems: implications for disease.

Frontiers in neuroendocrinology 2014
Bailey M, Silver R et al.

Virtually every eukaryotic cell has an endogenous circadian clock and a biological sex. These cell-based clocks have been conceptualized as oscillators whose phase can be reset by internal signals such as hormones, and external cues...

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In Vitro Study PubMed

Kisspeptin and neurokinin B: roles in reproductive health.

Physiological reviews 2025
Koysombat K, Tsoutsouki J, Patel AH et al.

Kisspeptin and neurokinin B (NKB) play a key role in several physiological processes including in puberty, adult reproductive function including the menstrual cycle, as well as mediating the symptoms of menopause. Infundibular kisspeptin neurons, which...

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Mechanism Study PubMed

Urinary phthalate/DINCH metabolites associations with kisspeptin and reproductive hormones in teenagers: A cross-sectional study from the HBM4EU aligned studies.

The Science of the total environment 2024
Rodríguez-Carrillo A, Remy S, Koppen G et al.

Exposure to phthalate/DINCH metabolites can induce human reproductive toxicity, however, their endocrine-disrupting mechanisms are not fully elucidated.

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Research Notice: All studies are presented for educational and informational purposes only. These compounds are for in vitro laboratory research use only (RUO). Not for human or animal use. Not evaluated or approved by the FDA.
Compound Information

Technical Specifications

🔬 Molecular Profile

TypeNeuropeptide
ClassificationNaturally Occurring
CAS Number374683-17-7
Mol. Weight1302.46 g/mol
SequenceTyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2 (Kp-10)
FormulaC63H83N15O13
OriginHypothalamus

🧊 Storage Requirements

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Lyophilized (powder) -20°C up to 2 years
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Reconstituted 2-8°C up to 30 days
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Working solution Use within 24 hours
Protect from light • Avoid repeated freeze-thaw cycles
Research Grade

Research-Grade Kisspeptin

≥98% purity, third-party COA verified, lyophilized for stability. For in vitro laboratory research use only.

⚠️ Research Use Only. Not for human or animal use. Not evaluated or approved by the FDA.

⚠️ Important Research Notice

All compounds listed are intended exclusively for in vitro laboratory research by qualified professionals. Not for human or animal consumption. Not approved by the FDA for any diagnostic, therapeutic, or clinical purpose. All research findings are sourced from peer-reviewed journals for educational reference only. Not to be interpreted as medical advice or product claims.